[Paper introduction] Cystine-glutamine mix reduces fatigue during endurance exercise by promoting fatty acid utilization

Exercise-induced fatigue is a phenomenon that is caused by a combination of physical and mental factors. Reducing these factors of fatigue leads to greater endurance and satisfaction, but to achieve this, athletes and trainers need to develop nutritional strategies to improve conditioning and performance.

It is becoming clear that amino acids in food are not just components of proteins, but also have functions that affect health. For example, glutamine and cysteine ​​are amino acids that have been reported to have antioxidant, anti-inflammatory, and immunomodulatory functions, and are expected to be applied to sports. In this study, we administered a cystine-glutamine mix for 7 days and investigated its effects on subjective fatigue (perceived exertion, RPE), energy metabolism, and inflammation in a randomized, placebo-controlled, double-blind, crossover study. We also investigated the effect of cystine on fatty acid utilization using a C2C12 myotube cell model.

As a result, it was observed that intake of the cystine-glutamine mix reduced RPE during 60 min of endurance exercise (Figure 1) and promoted fatty acid oxidation (Figure 2). In a C2C12 myotube cell model, cystine promoted fatty acid utilization by activating mitochondrial respiration (Figure 3).

Based on the above, it is speculated that taking cystine-glutamine mix is ​​effective in improving fatigue caused by exercise, and that the mechanism behind this is through promoting the efficiency of fatty acid utilization.

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original:https://www.mdpi.com/2075-4663/10/10/147

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